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Alprostadil is a hormone like substance that is referred to as prostaglandin E1, a known and potent vasodilator (improver of blood flow). Alprostadil has the power to directly effect the tissue that it comes into contact with. (3) An erection essentially occurs when the blood vessels widen in the genital region and allow the corpus caverosum to fill with blood, and hence the penis becomes erect and stiff. So, it is easy to see the direct role that alprostadil plays in the creation of an erection. go move Intercourse can be attempted with the constriction band in place to help maintain the erection. The band can be left on safely for up to 30 minutes to allow for successful intercourse. Vascular function within the penis can be evaluated with duplex ultrasonography. Patients are administered an intracavernosal test dose of a standard vasodilator, such as 20 mcg of prostaglandin E1 (PGE1), and the cavernosal arteries within the corpora are measured before and after the injection. A normal response indicates a peak systolic velocity of 0.35 m/s or more and an end diastolic velocity of -0.04 m/s or less. This is interpreted as adequate arterial blood flow (good peak systolic velocity) without evidence of a venous leak (end diastolic velocity below zero).